Metal Test Could Help Diagnose Breast Cancer Early

Metal Test Could Help Diagnose Breast Cancer Early
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It may be possible to develop a simple blood test that, by detecting changes in the zinc in our bodies, could help to diagnose breast cancer early. The researchers took techniques normally used to analyse trace metal isotopes for studying climate change and planetary formation and applied them to how the human body processes metals.
 
In a world-first the researchers were able to show that changes in the isotopic composition of zinc, which can be detected in a person's breast tissue, could make it possible to identify a biomarker of early breast cancer. The research was published in the Royal Society of Chemistry journal Metallomics.
 
The pilot study analysed zinc in the blood and blood serum of ten subjects (five breast cancer patients and five healthy controls) alongside a range of breast tissue samples from breast cancer patients. By using techniques that are over 100 times more sensitive to changes in the isotopic composition of metals than anything currently used by clinicians, the researchers were able to show that they could detect key differences in zinc caused when cancer subtly alters the way that cells process the metal. Similar changes in copper in one of the breast cancer patients is additional evidence that it may be possible to identify a biomarker for early breast cancer that could form the basis of a simple, non-invasive, diagnostic blood test.
 
The researchers say that this new understanding of cancer cell behaviour - in particular the role sulfur-containing proteins play in how tumours process zinc - could also help in the development of new cancer treatments. "Understanding how different cancers alter different trace metals within the body could enable us to develop both new diagnostic tools and new treatments that could lead to a 'two-pronged' attack on many cancers. Further research is already underway to see what changes in other metals may be caused by other cancers."