Narrow Subset Of Cells Responsible For Metastasis In Multiple Myeloma

Stable focal osteolytic bone lesions of skull and right humerus in a patient with multiple myeloma in complete remission for 5 y
Stable focal osteolytic bone lesions of skull and right humerus
in a patient with multiple myeloma in complete remission for
5 years. (Image source)
Although it is among the most highly metastatic of all cancers, multiple myeloma is driven to spread by only a subset of the myeloma cells within a patient's body, researchers found in a study presented at the annual meeting of the American Society of Hematology (ASH). The study suggests that attacking those subsets with targeted drugs may degrade the disease's ability to spread throughout the bone marrow of affected patients, the authors say.
The discovery was made by developing a mouse model of the disease that enabled researchers to track which of 15 genetic groups - or subclones - of myeloma cells spread beyond their initial site in the animals' hind legs. By labeling the different subgroups with fluorescent dyes, researchers determined that just one of the subclones was responsible for the disease metastasis. They then compared the pattern of gene abnormalities in the initial myeloma tissue and the metastatic tumors. They found that 238 genes were significantly less active in the latter group - comprising a gene "signature" of metastatic myeloma.
Out of all the genes that were differently expressed in the two groups, the researchers found 11 that played a functional role in metastasis and therefore may be drivers of the disease, the researchers concluded. If future studies confirm that role, the genes may become targets for therapies that block myeloma metastasis.