Novel Nanoparticle Therapy Promotes Wound Healing

Novel Nanoparticle Therapy Promotes Wound Healing
Imaging of burns indicates that those treated with the FL2
inhibitor nanotechnology experienced collagen deposition and
hair follicle formation. (2-photo confocal microscopy).
(Credit: Vera DesMarais/Albert Einstein College of Medicine)
An experimental therapy cut in half the time it takes to heal wounds compared to no treatment at all. Details of the therapy, which was successfully tested in mice, were published online in the Journal of Investigative Dermatology.
The researchers have earlier discovered that an enzyme called fidgetin-like 2 (FL2) puts the brakes on skin cells as they migrate towards wounds to heal them. They reasoned that the healing cells could reach their destination faster if their levels of FL2 could be reduced. So they developed a drug that inactivates the gene that makes FL2 and then put the drug in tiny gel capsules called nanoparticles and applied the nanoparticles to wounds on mice. The treated wounds healed much faster than untreated wounds.
The researchers plan to start testing the therapy on pigs, whose skin closely resembles that of humans, within months. They envision that the nanoparticle therapy could be used to speed the healing of all sorts of wounds, including everyday cuts and burns, surgical incisions, and chronic skin ulcers, which are a particular problem in the elderly and people with diabetes.
Based on material originally posted by Albert Einstein College of Medicine.