Cancer Drugs May Hold Key To Treating Brain Disorders

Cancer Drugs May Hold Key To Treating Brain Disorders
A class of FDA-approved cancer drugs may be able to prevent problems with brain cell development associated with disorders including Down syndrome and Fragile X syndrome, researchers have found.
The researchers’ proof-of-concept study using fruit fly models of brain dysfunction was published in the journal eLife. In it, they show that giving the leukemia drugs nilotinib or bafetinib to fly larvae with the equivalent of Fragile X prevented the wild overgrowth of neuron endings associated with the disorder. Meanwhile, the drugs - both tyrosine-kinase inhibitors - did not adversely affect the development or neuronal growth in healthy flies.
This proposes a potential therapeutic approach for treating brain disorders associated with dysregulated expression of the Dscam protein, which is seen in both Down syndrome and Fragile X syndrome.
Down syndrome and Fragile X are the two most prevalent genetic causes of intellectual disabilities. Down syndrome is caused by an extra copy of chromosome 21, while Fragile X is caused by a mutation in a single gene. Recent studies have pointed to a possible link between the two conditions.
During early development, neurons produce high levels of the proteins encoded by a gene called DSCAM as they undergo an intense period of extending and branching to connect with other neurons. (DSCAM stands for Down Syndrome Cell-Adhesion Molecule.) But problems can occur when Dscam levels don’t go back down.
In flies, when Dscam levels stay high, branches off of the ends of their neurons grow too long and make faulty connections with neighboring neurons. In humans, whose nervous systems and brains are far more complicated, the downstream impacts of Dscam dysregulation have not been fully identified.
In a series of experiments outlined in the study, the researchers showed that the Dscam protein activates another protein known as Abelson tyrosine kinase (Abl). The scientists then took genetically modified flies that produced high levels of Dscam and gave them the cancer drug, which acts by blocking the action of Abl.
In one experiment, directly overexpressing Dscam led to flies with neuron endings (called presynaptic terminals) more than 50 percent longer than normal, but flies treated with the cancer drug, showed only a 15 percent increase. In another experiment using a genetic model of Fragile X, the flies had presynaptic terminals almost a third longer than normal, but those who received the drug saw only 3 percent more terminal growth than the control group.
The next step will be to test the approach in mouse models of these brain disorders.

Based on material originally posted by University of Michigan.
(Image source)