Green Tea Extract And Exercise Hinder Progress Of Alzheimer's

Green Tea Extract And Exercise Hinder Progress Of Alzheimer's
Researchers have determined that a compound found in green tea, in combination with exercise, slows the progression of Alzheimer's disease (AD) in mice and may reverse its effects. Further study of the commonly found extract could lead to advancements in the treatment and prevention of Alzheimer's disease in humans. The findings were published in the Journal of Alzheimer's Disease.
Increases in inflammation have been linked to Alzheimer's disease patients and recent studies have suggested the benefits of dietary antioxidants in reducing the risk of AD. Researchers decided to investigate the effects of voluntary exercise and epigallocatechin-3-gallate (EGCG), a green tea extract, on memory function and A-beta levels in mice known to show plaque deposits and behavior deficits.
First, mice were placed in the center of a specialized maze and allowed to move around with the aim of finding the right hole, or "goal box." The researchers watched the mice to determine whether or not they could find the goal box, demonstrating memory and cognition.
In the second test, small "nestlets," or squares containing materials to create nests, were placed in the habitats for different groups of mice. A day later, nests were scored based on shape and the amount of material used.
Researchers then administered EGCG in the drinking water of the mice and gave them access to running or exercise wheels. After re-administering the maze and nesting tests, they found remarkable improvements in the cognitive function and retention in the Alzheimer's affected mice that were given EGCG and were allowed to exercise.
Consumption of natural products as potential remedies to prevent and treat diseases and to maintain human health is an ancient one. Future studies will further explore green tea extracts and other botanicals, also known as nutraceuticals.
Based on material originally posted by University of Missouri-Columbia.