Daily Aspirin Block Growth Of Breast Tumors


Daily Aspirin Block Growth Of Breast Tumors
A study published in the journal Laboratory Investigation has found that a daily dose of aspirin was effective at blocking breast tumor growth. Previous studies have already shown a similar effect on colon, gastrointestinal, prostate, and other cancers.
 
To test the theory that aspirin could alter the molecular signature in breast cancer cells enough that they wouldn't spread, the researchers used both incubated cells and mouse models. For the cell test, breast cancer cells were placed in 96 separate plates and then incubated. Just over half the cultures were exposed to differing doses of acetylsalicylic acid, commonly known as aspirin. Exposure to aspirin dramatically increased the rate of cell death in the test. For those cells that did not die off, many were left unable to grow.
 
The second part of the study involved studying 20 mice with aggressive tumors. For 15 days, half the mice were given the human equivalent of 75 milligrams of aspirin per day, which is considered a low dose. At the end of the study period, the tumors were weighed. Mice that received aspirin had tumors that were, on average, 47 percent smaller.
 
To show that aspirin could also prevent cancer, the researchers gave an additional group of mice aspirin for 10 days before exposing them to cancer cells. After 15 days, those mice had significantly less cancerous growth than the control group. This means that there are two parts that can be considered here. One could  administer aspirin after chemotherapy to prevent relapse and keep the pressure on, which was effective in both the laboratory and the mouse model in this study, as well as use it preventatively.

However, the researchers suggest patients consult with a doctor before starting a daily aspirin regimen. The drug is known to thin the blood and increase the risk of gastrointestinal bleeding.
 
Based on material originally posted by Veterans Affairs Research Communications.
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