Two years ago, researchers reported a new experimental immunotherapy that prevented the onset of Type 1 Diabetes in mice predisposed to the disease. Based on this work, an article published today in PLOS ONE describes a new step towards the creation of a vaccine, which in the medium-term could be capable of preventing and even curing the disease in humans.
Initially the researchers avoided the destruction of the insulin-producing pancreatic cells (beta cells) in the body by modifying the individual's immune cells, known as dendritic cells. This important step requires the extraction of the subjects' dendritic cells for their subsequent manipulation and re-injection. The process is complex and costly. In a new study with mice, researchers have achieved the same effect with a much simpler process. Nanoparticles called liposomes are created in the laboratory; when they are introduced into the body they arrest the destruction of the beta cells and avoid Diabetes development. This technique could be a much better candidate for a human vaccine. The invention is commercially protected and an international patent has been applied for.
Liposomes have been used in several medical treatments. They are not cells, but droplets with an external fat membrane, similar to cell membranes. They can be made using a very specialized process, but one that is easy and safe and also easy to scale up.
After showing that liposomes prevent the onset of Type 1 Diabetes in mice, the next steps are to test it in human cells in vitro, to start clinical trials on human candidates for preventive vaccination and to cure the disease by combining the vaccine with regenerative therapies. The researchers plan to carry out these steps with patients at the hospital and to optimize the product by dosage and guideline studies. It is also planned to optimize the product for personalization.
Growing incidence and complex consequences
Type 1 Diabetes is an illness where the body does not recognize the beta cells of the pancreas as its own and destroys them. The organ produces less and less insulin, the hormone that allows us to process the sugar we eat. Patients must prick their fingers several times a day to check blood sugar levels and inject themselves with insulin in the stomach or other parts of the body. This constant control is not always easy and having too much or too little insulin can have severe consequences. The most serious is that in the long term hyperglycemia provokes retinal damage that can lead to blindness, renal insufficiency, destruction of nerve fibers or what is called "Diabetics Foot" where ulcers form, leading eventually to the need to amputate.
The causes of the disease are unknown, although there are both genetic and environmental factors involved. About 0.3% of the population is affected and the incidence is increasing by 3-4% a year. It usually appears in children and young adults and it is incurable. This immunotherapy presents a possible solution for Type 1 Diabetes.
Based on material originally posted by Universitat Autonoma de Barcelona.