Identified Gene Could Hold Key To Treating Parkinson's

Identified Gene Could Hold Key To Treating Parkinson's
Image shows the larval stage of the fruit fly Drosophila. The
nerve cells in this larva are genetically engineered to produce a
green fluorescent protein (GFP), which helped researchers see
the nerves that had damaged mitochondria. By analysing nerves
with damaged mitochondria in larvae and adult flies, they
discovered that mitochondria produced a signal which blocked
nerve function.
Researchers have identified a new gene linked to nerve function, which could provide a treatment target for 'switching off' the gene in people with neurodegenerative diseases such as Parkinson's disease.
 
Parkinson's disease affects approximately 7-10 million people worldwide and is characterised by progressive loss of motor function, psychiatric symptoms and cognitive impairment.
 
Current treatments for Parkinson's only treat symptoms of the disease rather than its underlying causes, so these new findings in fruit flies could lead to novel preventative treatments if replicated in humans.
 
Previous research suggests that defects in mitochondria, which are tiny 'batteries' in cells that provide energy, play an important role in a number of diseases that affect the nervous system, including Parkinson's. However, until now the neuronal processes underlying the development of these conditions were unknown.
 
The study, published in PNAS, discovered that damaged mitochondria in fruit flies produce a signal which stops nerve cells from working. A gene called HIFalpha was found to regulate the nerve signals from damaged mitochondria and, when this gene was 'switched off' by the research team, nerve function in flies with Parkinson's disease was restored. By deactivating the HIFalpha gene, the early failure of nerve cells caused by mitochondrial damage was prevented.
 
An identical effect was observed in flies with Leigh syndrome, a rare neurological disorder caused by a severe mitochondrial defect, which typically arises in the first year of life in humans.
 
As the HIFalpha gene is also found in humans, this new finding could pave the way for new treatments in the future, according to the study authors.
 
Based on material originally posted by King's College London.