Safe And Inexpensive Chemical Reverse Symptoms Of Progeria

Safe And Inexpensive Chemical Reverse Symptoms Of Progeria
Progeria is a rare genetic disease that mimics the normal aging process at an accelerated rate. Symptoms typically appear within the first year of life, and individuals with the disease develop thin, wrinkled skin, fragile bones and joints, full-body hair loss and organ failure, among other complications. Most do not survive past their teen years.
 
New work from the University of Maryland suggests that a common, inexpensive and safe chemical called methylene blue could be used to treat progeria - and possibly the symptoms of normal aging as well. A new study shows for the first time that small doses of methylene blue can almost completely repair defects in cells afflicted with progeria, and can also repair age-related damage to healthy cells. The study was published in the journal Aging Cell.
 
"We tried very hard to examine the effect of methylene blue on all known progeria symptoms within the cell," said Kan Cao, senior author on the study. "It seems that methylene blue rescues every affected structure within the cell. When we looked at the treated cells, it was hard to tell that they were progeria cells at all. It's like magic."
 
Progeria results from a defect in a single gene. This gene produces a protein called lamin A, which sits just inside the cell's nucleus, under the nuclear membrane. Healthy cells snip off a small piece of each new lamin A molecule--a small edit that is necessary for lamin A to work properly. Cells with progeria, however, skip this important editing step. The defective lamin A interferes with the nuclear membrane, causing the nucleus to form bulges and deformations that make normal functioning impossible.
 
Cells with progeria also have misshapen and defective mitochondria, which are the small organelles that produce energy for the cell. Although previous studies suggested damage to mitochondria in progeria cells, the current study is the first to document the nature and extent of this damage in detail. Cao and her colleagues found that a majority of the mitochondria in progeria cells become swollen and fragmented, making it impossible for the defective mitochondria to function.
Methylene blue successfully repaired progeria-related
defects in the nuclei of human fibroblast cells affected
by the disease. The nuclei of untreated cells (panels 1
and 2, left) still exhibit the abnormal convoluted shape
characteristic of progeria. The nuclei of cells treated with
methylene blue for 8 weeks (panels 3 and 4, right)
returned to their normal, rounded shape. The top images
were stained with antibodies that attach to the normal
lamin A protein, while the bottom images were stained
with antibodies that attach to defective lamin A, also
known as progerin. (Credit: Kan Cao/Zheng-Mei Xiong)
 
The team found that methylene blue reverses the damages to both the nucleus and mitochondria in progeria cells remarkably well. The precise mechanism is still unclear, but treating the cells with the chemical effectively improved every defect, causing progeria cells to be almost indistinguishable from normal cells.
 
The researchers also tested methylene blue in healthy cells allowed to age normally. The normal aging process degrades mitochondria over time, causing these older mitochondria to resemble the mitochondria seen in progeria cells. Once again, methylene blue repaired these damages.
 
Because methylene blue can repair the cell defects that ultimately lead to whole-body symptoms in progeria patients, the researchers believe methylene blue could be used as a treatment for the disease in the future. Similarly, methylene blue could show promise as an over-the-counter treatment for the symptoms of normal aging, perhaps as an additive to cosmetic products or nutritional supplements.
 
The researchers are now working to complete the next crucial step: testing in animal models.
 
Based on material originally posted by University of Maryland.
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